4AT3 Chain A
BDNF/NT-3 growth factors receptor (NTRK2)
Inactive — 0.0%DFG-inαC-outType1 · LTI
Resolution
1.77 Å
R-value
0.2
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GAMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCKILVAVKTLASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMANPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
UniProt reference sequence
IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN
Aligned reference sequence
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLCPEQ-------------------------------DKILVAVKTLK--DASDNA----------------------------RKDFHREAELLTNL--------------------------QHEHIVKFYGVCVEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAVLMAEGNPPT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTQSQMLHIAQQIAAGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSLGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNNEVIECITQG--RVLQRPRTCP-----------------------------------------------------------------------------------------------------QEVYELMLGCWQREPHMRKN--------------IKGIHTLLQN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLC-----------------------------------KILVAVKTL----ASDNA----------------------------RKDFHREAELLTNL--------------------------QHEHIVKFYGVCVEGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAVLMA--NPPT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELTQSQMLHIAQQIAAGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSR--YSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSLGVVLWEIFTY--G--------------KQPWYQ--------------------------------------------------LSNNEVIECITQG--RVLQRPRTCP-----------------------------------------------------------------------------------------------------QEVYELMLGCWQREPHMRKN--------------IKGIHTLLQN
Activation segment
DFGMSR--YSTDYY--RVG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPE
Binding pocket
RELGEGAFGKVFLVAVKTLDFHREAELLTNLQEHIVKFYGVIMVFEYMKHGDLNKFLRAYLASQHFVHRDLATRNCLVIGDFGMS
Ligand info
Orthosteric ligand
LTI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4AT3, Chain A