4AGU Chain B
Cyclin-dependent kinase-like 1 (CDKL1)
Inactive — 6.7%DFG-inαC-inType1 · D15
Resolution
2.4 Å
R-value
0.189
Predicted activity confidence6.7%
Structure info
Alternate conformation—
Missing atoms46
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE
UniProt reference sequence
YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYF
Aligned reference sequence
YEKI----------------GKIGEGS----------------YGVVFKCRN--RD------------------------------------TGQIVAIKKFL--ESEDDPVI--------------------------KKIALREIRMLKQL--------------------------KHPNLVNLLEVFRRKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLHLVFEYCD---------------HTVLHELDR--YQR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEHLVKSITWQTLQAVNFCHKH---------------------------------------------NCIHRDV-----KPENILITK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSVIKLCDFGFARLLAGPSDY--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDYVATRWYRSPELLVG--D-----------------------------TQYG-PPVDVWAIGCVFAELLSG-----------------VPLWPG--------------------------------------------------KSDVDQLYLIRKT--LGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNIS-----------------------------------------------------------------------YPALGLLKGCLHMDPTQRLT--------------CEQLLHHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEKI----------------GKIGEGS----------------YGVVFKCRN--RD------------------------------------TGQIVAIKKFL--ES--DPVI--------------------------KKIALREIRMLKQL--------------------------KHPNLVNLLEVFRRKR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLHLVFEYCD---------------HTVLHELDR--YQR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPEHLVKSITWQTLQAVNFCHKH---------------------------------------------NCIHRDV-----KPENILITK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HSVIKLCDFGFARLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRWYRSPELLVG--D-----------------------------TQYG-PPVDVWAIGCVFAELLSG-----------------VPLWPG--------------------------------------------------KSDVDQLYLIRKT--LGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNIS-----------------------------------------------------------------------YPALGLLKGCLHMDPTERLT--------------CEQLLHHPYF
Activation segment
DFGFARLL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRWYRSPE
Binding pocket
GKIGEGSYGVVFKVAIKKFIALREIRMLKQLKPNLVNLLEVHLVFEYCD_HTVLHELDRFCHKHNCIHRDVKPENILILCDFGFA
Ligand info
Orthosteric ligand
D15
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4AGU, Chain B