4AAA Chain A
Cyclin-dependent kinase-like 2 (CDKL2)
Inactive — 0.0%DFG-inαC-outType1 · DKI
Resolution
1.53 Å
R-value
0.182
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms9
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
LYFQSMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFAEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQMDGFAERFSQELQL
UniProt reference sequence
YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF
Aligned reference sequence
YENL----------------GLVGEGS----------------YGMVMKCRN--KD------------------------------------TGRIVAIKKFL--ESDDDKMV--------------------------KKIAMREIKLLKQL--------------------------RHENLVNLLEVCKKKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RWYLVFEFVD---------------HTILDDLEL--FPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH---------------------------------------------NIIHRDI-----KPENILVSQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGVVKLCDFGFARTLAAPGEV--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDYVATRWYRAPELLVG--D-----------------------------VKYG-KAVDVWAIGCLVTEMFMG-----------------EPLFPG--------------------------------------------------DSDIDQLYHIMMC--LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLS-----------------------------------------------------------------------EVVIDLAKKCLHIDPDKRPF--------------CAELLHHDFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YENL----------------GLVGEGS----------------YGMVMKCRN--KD------------------------------------TGRIVAIKKFL--ESDDDKMV--------------------------KKIAMREIKLLKQL--------------------------RHENLVNLLEVCKKKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RWYLVFEFVD---------------HTILDDLEL--FPN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLDYQVVQKYLFQIINGIGFCHSH---------------------------------------------NIIHRDI-----KPENILVSQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGVVKLCDFGFA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVATRWYRAPELLVG--D-----------------------------VKYG-KAVDVWAIGCLVTEMFMG-----------------EPLFPG--------------------------------------------------DSDIDQLYHIMMC--LGNLIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLS-----------------------------------------------------------------------EVVIDLAKKCLHIDPDKRPF--------------CAELLHHDFF
Activation segment
DFGFA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVATRWYRAPE
Binding pocket
GLVGEGSYGMVMKVAIKKFIAMREIKLLKQLRENLVNLLEVYLVFEFVD_HTILDDLELFCHSHNIIHRDIKPENILVLCDFGFA
Ligand info
Orthosteric ligand
DKI
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 4AAA, Chain A