3ZXT Chain D
Death-associated protein kinase 1 (DAPK1)
Inactive — 0.3%DFG-inαC-inATPlike · ACP
Resolution
2.65 Å
R-value
0.219
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms54
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAETEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK
UniProt reference sequence
YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWI
Aligned reference sequence
YDTG----------------EELGSGQ----------------FAVVKKCRE--KS------------------------------------TGLQYAAKFIK--KRRTKSSRRGVS----------------------REDIEREVSILKEI--------------------------QHPNVITLHEVYENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVILILELVAG--------------GELFDFLAE--KE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLLD--RNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPRIKIIDFGLAHKIDFGNEF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KNIFGTPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YDTG----------------EELGSGQ----------------FAVVKKCRE--KS------------------------------------TGLQYAAKFI-------------VS----------------------REDIEREVSILKEI--------------------------QHPNVITLHEVYENKT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVILILELVAG--------------GELFDFLAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TEEEATEFLKQILNGVYYLHSL---------------------------------------------QIAHFDL-----KPENIMLLD--RNVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KPRIKIIDFGLAHKID----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPEFVAPEIVNY--------------------------------EPLG-LEADMWSIGVITYILLSG-----------------ASPFLG--------------------------------------------------DTKQETLANVSAV--NYEFEDEYFSNTS--------------------------------------------------------------------------------------------------ALAKDFIRRLLVKDPKKRMT--------------IQDSLQHPWI
Activation segment
DFGLAHKID----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPEFVAPE
Binding pocket
EELGSGQFAVVKKYAAKFIDIEREVSILKEIQPNVITLHEVILILELVAGGELFDFLAEYLHSLQIAHFDLKPENIMLIIDFGLA
Ligand info
Orthosteric ligand
ACP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ZXT, Chain D