3ZFX Chain E
Ephrin type-B receptor 1 (EPHB1)
Inactive — 43.8%DFG-inαC-in
Resolution
2.5 Å
R-value
0.19
Predicted activity confidence43.8%
Structure info
Alternate conformation—
Missing atoms7
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AKEIDVSFVKIEEVIGAGEVYKGRLKLKREIYVAIKTLKASEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVAT
UniProt reference sequence
VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVYKGRL--KLPGK---------------------------------REIYVAIKTLK--AGYSEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GALDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLAEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRYLQDDTSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPVRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR--------------FAEIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGA-------------------GEVYKGRL--KL--K---------------------------------REIYVAIKTLK--A--SEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTKSR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GALDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLAEM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRYL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIPVRWTAPEAIAY--------------------------------RKFT-SASDVWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR--------------FAEIVNTLDK
Activation segment
DFGLSRYL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKIPVRWTAPE
Binding pocket
EVIGAGE___VYKVAIKTLDFLSEASIMGQFDPNIIRLEGVMIITEFMENGALDSFLRQYLAEMNYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ZFX, Chain E