3ZFM Chain A
Ephrin type-B receptor 2 (EPHB2)
Inactive — 0.0%DFG-inαC-in
Resolution
2.27 Å
R-value
0.236
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms10
Missing residues7
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
EIDISCVKIEQVIFGEVCSGHLKLPGKREIFVAIKTLTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMA
UniProt reference sequence
VKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDK
Aligned reference sequence
VKIE----------------QVIGAGE----------------FGEVCSGHL--KLPGK---------------------------------REIFVAIKTLK--SGYTEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEDDTSD--PTYTSA----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------QVI--------------------FGEVCSGHL--KLPGK---------------------------------REIFVAIKTL------TEKQ---------------------------RRDFLSEASIMGQF--------------------------DHPNVIHLEGVVTKST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIITEFMEN--------------GSLDSFLRQ--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMKYLADM---------------------------------------------NYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MTNQDVINAIEQD--YRLPPPMDCP-----------------------------------------------------------------------------------------------------SALHQLMLDCWQKDRNHRPK--------------FGQIVNTLDK
Activation segment
DF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PIRWTAPE
Binding pocket
QVI____FGEVCSVAIKTLDFLSEASIMGQFDPNVIHLEGVMIITEFMENGSLDSFLRQYLADMNYVHRDLAARNILVVSDF___
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ZFM, Chain A