3ZEW Chain A
Ephrin type-B receptor 4 (EPHB4)
Inactive — 18.9%DFG-inαC-inType1 · STU
Resolution
2.5 Å
R-value
0.24
Predicted activity confidence18.9%
Structure info
Alternate conformationB
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLSSDPTTSSKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVA
UniProt reference sequence
VKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDK
Aligned reference sequence
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTLK--GGYTERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFLEENSSD--PTYTSS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGGKIPIRWTAPEAIAF--------------------------------RKFT-SASDAWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQVVSALDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VKIE----------------EVIGAGE----------------FGEVCRGRL--KAPGK---------------------------------KESCVAIKTL------TERQ---------------------------RREFLSEASIMGQF--------------------------EHPNIIRLEGVVTNSM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMILTEFMEN--------------GALDSFLRL--NDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIASGMRYLAEM---------------------------------------------SYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRFL---SSD--PT-TSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTAPEAIAF--------------------------------RKFT-SASDAWSYGIVMWEVMSF--G--------------ERPYWD--------------------------------------------------MSNQDVINAIEQD--YRLPPPPDCP-----------------------------------------------------------------------------------------------------TSLHQLMLDCWQKDRNARPR--------------FPQVVSALDK
Activation segment
DFGLSRFL---SSD--PT-TSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KIPIRWTAPE
Binding pocket
EVIGAGEFGEVCRVAIKTLEFLSEASIMGQFEPNIIRLEGVMILTEFMENGALDSFLRLYLAEMSYVHRDLAARNILVVSDFGLS
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ZEW, Chain A