3ZC6 Chain A
Tyrosine-protein kinase JAK3 (JAK3)
Active — 99.8%DFG-inαC-inType1 · VFC
Resolution
2.42 Å
R-value
0.193
Predicted activity confidence99.8%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
PTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDVVQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWS
UniProt reference sequence
LEWHENLGHGSFTKIYRGCRHEVVDGEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDSTMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVSARKVLLAREGADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNS
Aligned reference sequence
LEWH----------------ENLGHGS----------------FTKIYRGCR--HEVVDGEA------------------------------RKTEVLLKVMD--AKHKNC----------------------------MESFLEAASLMSQV--------------------------SYRHLVLLHGVCMAG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSTMVQEFVHL--------------GAIDMYLRK--RGH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPASWKLQVVKQLAYALNYLEDK---------------------------------------------GLPHGNV-----SARKVLLAR--EGADGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPFIKLSDPGVSPAVLSL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EMLTDRIPWVAPECLRE--A-----------------------------QTLS-LEADKWGFGATVWEVFSG--V--------------TMPISA--------------------------------------------------LDPAKKLQFYEDR--QQLPAPKW-------------------------------------------------------------------------------------------------------TELALLIQQCMAYEPVQRPS--------------FRAVIRDLNS
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKYI----------------SQLGKGN----------------F-GSVELCR-----YDPLG------------------------------DNTGALVAVKQ--LQHFQR----------------------------EIQILKALHSDFIV--------------------------KYR------GV-SYG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLRLVMEYLPS--------------GCLRDFLQR--HRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDASRLLLYSSQICKGMEYL------------------------------------------------------G-----SRRCVLAAR--NILVES------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EAHVKIADFGLAKLLLDK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVQSPIFWYAPESL-S--D-----------------------------NIFS-RQSDVWSFGVVLYELFEF--L--------------RMMGSE--------------------------------------------------RDPARLLELLEEG--QRLPAPCP-------------------------------------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS--------------FSAQLDMLWS
Activation segment
DFGLAKLLLDK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVVQSPIFWYAPE
Binding pocket
SQLGKGNFGSVELVAVKQLDFQREIQILKALHDFIVKYRGVRLVMEYLPSGCLRDFLQRYLGSRRCVHRDLAARNILVIADFGLA
Ligand info
Orthosteric ligand
VFC
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3ZC6, Chain A