3W2C Chain C
Aurora kinase A (AURKA)
Inactive — 0.1%DFG-outαC-outType1 · N15
Resolution
2.45 Å
R-value
0.256
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms4
Missing residues17
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
WALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQEVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCKPENLLLGSAGELKIADTLDYLPPEMIEVDLWSLGVLCYEFLVGKPPFEANTYQYKRISRVEFTFPDFVTEGARDLISRLLKHNPHPWITANSS
UniProt reference sequence
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVHAPSSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLCGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQ-------------------------------------EVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYC------------------------------------------------------------KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIAD------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDYLPPEMIE----------------------------------------VDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQ--YKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNP-------------------------HPWI
Activation segment
D------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDYLPPE
Binding pocket
RPLGKGKFGNVYLLALKVLQ___EVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYC__________KPENLLLIAD____
Ligand info
Orthosteric ligand
N15
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3W2C, Chain C