3V5Q Chain A
NT-3 growth factor receptor (NTRK3)
Inactive — 0.0%DFG-outαC-inType2 · 0F4
Resolution
2.2 Å
R-value
0.214
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms4
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GIHVQHIKRRDIVLKRELKVFLAECYNLSPTKDKMLVAVKALPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMDVYSTDYYRTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATP
UniProt reference sequence
IVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHA
Aligned reference sequence
IVLK----------------RELGEGA----------------FGKVFLAEC--YNLSPTK-------------------------------DKMLVAVKALK--DPTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGPDAMILVDGQPRQAKG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGMSRDVYSTDYY--RLFNPSGNDFCIWCEVG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GHTMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLK----------------REL----------------------KVFLAEC--YNLSPTK-------------------------------DKMLVAVKAL----PTLAA----------------------------RKDFQREAELLTNL--------------------------QHEHIVKFYGVCGDGD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLIMVFEYMKH--------------GDLNKFLRA--HGP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELGLSQMLHIASQIASGMVYLASQ---------------------------------------------HFVHRDL-----ATRNCLVGA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLLVKIGDFGM--DVYSTDYY--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMLPIRWMPPESIMY--------------------------------RKFT-TESDVWSFGVILWEIFTY--G--------------KQPWFQ--------------------------------------------------LSNTEVIECITQG--RVLERPRVCP-----------------------------------------------------------------------------------------------------KEVYDVMLGCWQREPQQRLN--------------IKEIYKILHA
Activation segment
DFGM--DVYSTDYY--R-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMLPIRWMPPE
Binding pocket
REL______KVFLVAVKALDFQREAELLTNLQEHIVKFYGVIMVFEYMKHGDLNKFLRAYLASQHFVHRDLATRNCLVIGDFGM_
Ligand info
Orthosteric ligand
0F4
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3V5Q, Chain A