3UIU Chain A
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)
Inactive — 2.9%DFG-inαC-in
Resolution
2.9 Å
R-value
0.247
Predicted activity confidence2.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
ETKYTVDKRFGMDFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLTLRYMSPEQIYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKK
UniProt reference sequence
FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAEREVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTV
Aligned reference sequence
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIKRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPETSDDSLESSDYDPENSKNSSRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSLKNDGKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRSKGTLRYMSPEQISS--------------------------------QDYG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FKEI----------------ELIGSGG----------------FGQVFKAKH--RI------------------------------------DGKTYVIRRVK--YN--------------------------------NEKAEREVKALAKL--------------------------DHVNIVHYNGCWDGFD--YDPET------------------SRSKTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CLFIQMEFCDK--------------GTLEQWIEK--RRGE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLDKVLALELFEQITKGVDYIHSK---------------------------------------------KLIHRDL-----KPSNIFLVD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TKQVKIGDFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLRYMSPEQI------------------------------------YG-KEVDLYALGLILAELLHV-------------------------CDTA--------------------------------------------FETSKFFTDLRDG--IISDIFD--------------------------------------------------------------------------------------------------------KKEKTLLQKLLSKKPEDRPN--------------TSEILRTLTV
Activation segment
DFGLVTSL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLRYMSPE
Binding pocket
ELIGSGGFGQVFKYVIRRVKAEREVKALAKLDVNIVHYNGCFIQMEFCDKGTLEQWIEKYIHSKKLIHRDLKPSNIFLIGDFGLV
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3UIU, Chain A