3TXO Chain A
Protein kinase C eta type (PRKCH)
Inactive — 37.4%DFG-inαC-inType1 · 07U
Resolution
2.05 Å
R-value
0.212
Predicted activity confidence37.4%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLPIDEGHLPMINQDEFRNFEYVSP
UniProt reference sequence
FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
Aligned reference sequence
FEFI----------------RVLGKGS----------------FGKVMLARV--KE------------------------------------TGDLYAVKVLK--KDVILQDDD-------------------------VECTMTEKRILSLA--R-----------------------NHPFLTQLFCCFQTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVMEFVNG--------------GDLMFHIQK--SR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFDEARARFYAAEIISALMFLHDK---------------------------------------------GIIYRDL-----KLDNVLLDH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHCKLADFGMCKEGICNGVT--T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATFCGTPDYIAPEILQE--------------------------------MLYG-PAVDWWAMGVLLYEMLCG-----------------HAPFEA--------------------------------------------------ENEDDLFEAILND--EVVYPTWLH------------------------------------------------------------------------------------------------------EDATGILKSFMTKNPTMRLG--SLTQGG------EHAILRHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEFI----------------RVLGKGS----------------FGKVMLARV--KE------------------------------------TGDLYAVKVLK--KDVILQDDD-------------------------VECTMTEKRILSLA--R-----------------------NHPFLTQLFCCFQTPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLFFVMEFVNG--------------GDLMFHIQK--SR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFDEARARFYAAEIISALMFLHDK---------------------------------------------GIIYRDL-----KLDNVLLDH--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGHCKLADFGMCKEGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPDYIAPEILQE--------------------------------MLYG-PAVDWWAMGVLLYEMLCG-----------------HAPFEA--------------------------------------------------ENEDDLFEAILND--EVVYPTWLH------------------------------------------------------------------------------------------------------EDATGILKSFMTKNPTMRLG--SLTQGG------EHAILRHPFF
Activation segment
DFGMCKEGI--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTPDYIAPE
Binding pocket
RVLGKGSFGKVMLYAVKVLCTMTEKRILSLARPFLTQLFCCFFVMEFVNGGDLMFHIQKFLHDKGIIYRDLKLDNVLLLADFGMC
Ligand info
Orthosteric ligand
07U
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3TXO, Chain A