3RI1 Chain B
Fibroblast growth factor receptor 2 (FGFR2)
Active — 98.0%DFG-inαC-inType1 · 3RH
Resolution
2.1 Å
R-value
0.216
Predicted activity confidence98.0%
Structure info
Alternate conformation—
Missing atoms16
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN
UniProt reference sequence
LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
Aligned reference sequence
LTLG----------------KPLGEGC----------------FGQVVMAEA--VGIDKDKPK-----------------------------EAVTVAVKMLK--DDATEKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLRA--RRPPGMEYSYDINRVPEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMTFKDLVSCTYQLARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVMKIADFGLARDINNIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLMWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLG----------------KPLGEGC----------------FGQVVMAEA--VGID---PK-----------------------------EAVTVAVKMLK--DDATEKD---------------------------LSDLVSEMEMMKMI--G-----------------------KHKNIINLLGACTQDG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLYVIVEYASK--------------GNLREYLRA--RRPP-------------E---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QMTFKDLVSCTYQLARGMEYLASQ---------------------------------------------KCIHRDL-----AARNVLVTE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVMKIADFGLARDINNIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPEALFD--------------------------------RVYT-HQSDVWSFGVLMWEIFTL--G--------------GSPYPG--------------------------------------------------IPVEELFKLLKEG--HRMDKPANCT-----------------------------------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT--------------FKQLVEDLDR
Activation segment
DFGLARDINNIDYY--KKT-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNGRLPVKWMAPE
Binding pocket
KPLGEGCFGQVVMVAVKMLDLVSEMEMMKMIGKNIINLLGAYVIVEYASKGNLREYLRAYLASQKCIHRDLAARNVLVIADFGLA
Ligand info
Orthosteric ligand
3RH
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3RI1, Chain B