3RCD Chain B
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Inactive — 0.1%DFG-inαC-in
Resolution
3.21 Å
R-value
0.227
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ALLRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNLDSTFYRSLLE
UniProt reference sequence
LRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSR
Aligned reference sequence
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR--ENTSPKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFGLARLLDIDETE--YHA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGGKVPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRKV----------------KVLGSGA----------------FGTVYKGIW--IPDGEN--------------------------------VKIPVAIKVLR------PKA---------------------------NKEILDEAYVMAGV--------------------------GSPYVSRLLGICLTS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVQLVTQLMPY--------------GCLLDHVRE--NRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLGSQDLLNWCMQIAKGMSYLEDV---------------------------------------------RLVHRDL-----AARNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNHVKITDFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALESILR--------------------------------RRFT-HQSDVWSYGVTVWELMTF--G--------------AKPYDG--------------------------------------------------IPAREIPDLLEKG--ERLPQPPICT-----------------------------------------------------------------------------------------------------IDVYMIMVKCWMIDSECRPR--------------FRELVSEFSR
Activation segment
DFG---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VPIKWMALE
Binding pocket
KVLGSGAFGTVYKVAIKVLEILDEAYVMAGVGPYVSRLLGIQLVTQLMPYGCLLDHVREYLEDVRLVHRDLAARNVLVITDFG__
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3RCD, Chain B