3QUP Chain A
Tyrosine-protein kinase receptor TYRO3 (TYRO3)
Inactive — 0.0%DFG-outαC-outType1 · LUN
Resolution
1.9 Å
R-value
0.239
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
EDVLIPFTLGRMLGKGEFGSVREAQLVKVAVKMLSSDIEEFLREAACMKEFDHPHVAKLVGVSLRSIPMVILPFMKHGDLHAFLLASRIPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH
UniProt reference sequence
FTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELEN
Aligned reference sequence
FTLG----------------RMLGKGE----------------FGSVREAQL--KQEDG---------------------------------SFVKVAVKMLK--ADIIASSD--------------------------IEEFLREAACMKEF--------------------------DHPHVAKLVGVSLRSR--AKGRLP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPMVILPFMKH--------------GDLHAFLLA--SRIGENPF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPLQTLIRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGLSRKIYSGDYY--RQG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CASKLPVKWLALESLAD--------------------------------NLYT-VQSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-----------------------------------------------------------------------------------------------------EDVYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTLG----------------RMLGKGE----------------FGSVREAQL------------------------------------------VKVAVKML--------SSD--------------------------IEEFLREAACMKEF--------------------------DHPHVAKLVGVSLRS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IPMVILPFMKH--------------GDLHAFLLA--SRI---PF-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLPLQTLVRFMVDIACGMEYLSSR---------------------------------------------NFIHRDL-----AARNCMLAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTVCVADFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWLALESLAD--------------------------------NLYT-VHSDVWAFGVTMWEIMTR--G--------------QTPYAG--------------------------------------------------IENAEIYNYLIGG--NRLKQPPECM-----------------------------------------------------------------------------------------------------EEVYDLMYQCWSADPKQRPS--------------FTCLRMELEN
Activation segment
DFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPVKWLALE
Binding pocket
RMLGKGEFGSVREVAVKMLEFLREAACMKEFDPHVAKLVGVMVILPFMKHGDLHAFLLAYLSSRNFIHRDLAARNCMLVADFGL_
Ligand info
Orthosteric ligand
LUN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3QUP, Chain A