3QD2 Chain B
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Active — 99.3%DFG-outαC-in
Resolution
2.81 Å
R-value
0.273
Predicted activity confidence99.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ASRYLTDFEPIQCMGRGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLETPPEKWQEEMDEPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDTHGQVTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYSFSTQMERVRIITDVRNLKFPLLFTQKYPQEHMMVQDMLSPSPTERPEATDIIENAIFENL
UniProt reference sequence
FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLEAPPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVF
Aligned reference sequence
FEPI----------------QCLGRGG----------------FGVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLEAP--PEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSRSFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGNDEGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAFKPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKV--YLYIQMQLCRK--------------ENLKDWMNG--RCTIE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ERERSVCLHIFLQIAEAVEFLHSK---------------------------------------------GLMHRDL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDFGLVTAMDQDEEE--QTVLTPMPAYARH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGQVGTKLYMSPEQIHG--------------------------------NSYS-HKVDIFSLGLILFELLYP-------------------------FSTQ--------------------------------------------MERVRTLTDVRNL--KFPPLFTQKY-----------------------------------------------------------------------------------------------------PCEYVMVQDMLSPSPMERPE--------------AINIIENAVF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEPI----------------QCMGR-G----------------FGVVFEAKN--KV------------------------------------DDCNYAIKRIR--LPNRELA---------------------------REKVMREVKALAKL--------------------------EHPGIVRYFNAWLETP--PEKWQEEMDE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKV--YLYIQMQLCRK--------------ENLKDWMNR--RCSLE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DREHGVCLHIFIQIAEAVEFLHSK---------------------------------------------GLMHRDL-----KPSNIFFTM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDVVKVGDFGLVTAMDQD-----------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGQV-TKLYMSPEQIHG--------------------------------NNYS-HKVDIFSLGLILFELLYS-------------------------FSTQ--------------------------------------------MERVRIITDVRNL--KFPLLFTQKY-----------------------------------------------------------------------------------------------------PQEHMMVQDMLSPSPTERPE--------------ATDIIENAIF
Activation segment
DFGLVTAMDQD-----------------T---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGQV-TKLYMSPE
Binding pocket
GRGFGVVFEAKNKKRIRLPVMREVKALAKLEHGIVRYFNAWKWQEEMDEPKVYLYIQMQ__HSKGLMHRDLKPSNIFFDFGLVTA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3QD2, Chain B