3Q4U Chain A
Activin receptor type-1 (ACVR1)
Active — 99.4%DFG-inαC-inType1 · LDN
Resolution
1.82 Å
R-value
0.166
Predicted activity confidence99.4%
Structure info
Alternate conformationA
Missing atoms5
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RTVARDITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKID
UniProt reference sequence
ITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTK
Aligned reference sequence
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLL----------------ECVGKGR----------------YGEVWRGSW----------------------------------------QGENVAVKIFS--SRD-------------------------------EKSWFRETELYNTV--ML----------------------RHENILGFIASDMTSR--HSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEM--------------GSLYDYLQL--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDTVSCLRIVLSIASGLAHLHIE--IFGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGQCCIADLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--TIQVDC------------------------FDSY-KRVDIWAFGLVLWEVARR--MVSNGIVEDY-----KPPFYD--VVPND-------------------------------------------PSFEDMRKVVCVD--QQRPNIPNRWFSDPTL-----------------------------------------------------------------------------------------------TSLAKLMKECWYQNPSARLT--------------ALRIKKTLTK
Activation segment
DLGLAVMHSQSTNQ--LDVGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETELYNTVMENILGFIASWLITHYHEMGSLYDYLQLTQGKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
LDN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3Q4U, Chain A