3PLS Chain A
Macrophage-stimulating protein receptor (MST1R)
Inactive — 0.5%DFG-inαC-outATPlike · ANP
Resolution
2.24 Å
R-value
0.235
Predicted activity confidence0.5%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RDLDSALLAEVKDVLIPHERVVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSALLGDHYVQLP
UniProt reference sequence
VVTHSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQ
Aligned reference sequence
VVTH--SD------------RVIGKGH----------------FGVVYHGEY--IDQAQ---------------------------------NRIQCAIKSLS--RITEMQQ---------------------------VEAFLREGLLMRGL--------------------------NHPNVLALIGIMLPPE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPHVLLPYMCH--------------GDLLQFIRS--PQR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLISFGLQVARGMEYLAEQ---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFTVKVADFGLARDILDREYY--SVQQH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHARLPVKWMALESLQT--------------------------------YRFT-TKSDVWSFGVLLWELLTR--G--------------APPYRH--------------------------------------------------IDPFDLTHFLAQG--RRLPQPEYCP-----------------------------------------------------------------------------------------------------DSLYQVMQQCWEADPAVRPT--------------FRVLVGEVEQ
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VVTH--SD------------RVIGKGH----------------FGVVYHGEY--IDQAQ---------------------------------NRIQCAIKSLS--RITEMQQ---------------------------VEAFLREGLLMRGL--------------------------NHPNVLALIGIMLPPE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LPHVLLPYMCH--------------GDLLQFIRS--PQR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLISFGLQVARGMEYLAEQ---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SFTVKVADFGLARDILDREYY--SVQQH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHARLPVKWTALESLQT--------------------------------YRFT-TKSDVWSFGVLLWELLTR--G--------------APPYRH--------------------------------------------------IDPFDLTHFLAQG--RRLPQPEYCP-----------------------------------------------------------------------------------------------------DSLYQVMQQCWEADPAVRPT--------------FRVLVGEVEQ
Activation segment
DFGLARDILDREYY--SVQQH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RHARLPVKWTALE
Binding pocket
RVIGKGHFGVVYHCAIKSLAFLREGLLMRGLNPNVLALIGIHVLLPYMCHGDLLQFIRSYLAEQKFVHRDLAARNCMLVADFGLA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3PLS, Chain A