3P1A Chain A
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)
Active — 94.5%DFG-inαC-in
Resolution
1.7 Å
R-value
0.152
Predicted activity confidence94.5%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
QLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQP
UniProt reference sequence
FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVL
Aligned reference sequence
FQRL----------------SRLGHGS----------------YGEVFKVRS--KE------------------------------------DGRLYAVKRSM--SPFRGPKD--------------------------RARKLAEVGSHEKV--G-----------------------QHPCCVRLEQAWEEGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILYLQTELCG---------------PSLQQHCEA--WGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLPEAQVWGYLRDTLLALAHLHSQ---------------------------------------------GLVHLDV-----KPANIFLGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRCKLGDFGLLVELGTAGAG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVQEGDPRYMAPELLQ---------------------------------GSYG-TAADVFSLGLTILEVACN-------------------------MEL---------------------------------------------PHGGEGWQQLRQG--YLPPEFTAGLS----------------------------------------------------------------------------------------------------SELRSVLVMMLEPDPKLRAT--------------AEALLALPVL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FQRL----------------SRLGHGS----------------YGEVFKVRS--KE------------------------------------DGRLYAVKRSM--SPFRGPKD--------------------------RARKLAEVGSHEKV--G-----------------------QHPCCVRLEQAWEEGG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ILYLQTELCG---------------PSLQQHCEA--WGA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLPEAQVWGYLRDTLLALAHLHSQ---------------------------------------------GLVHLDV-----KPANIFLGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGRCKLGDFGLLVELG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQEGDPRYMAPELLQ---------------------------------GSYG-TAADVFSLGLTILEVACN-------------------------MEL---------------------------------------------PHGGEGWQQLRQG--YLPPEFTAGLS----------------------------------------------------------------------------------------------------SELRSVLVMMLEPDPKLRAT--------------AEALLALPVL
Activation segment
DFGLLVELG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VQEGDPRYMAPE
Binding pocket
SRLGHGSYGEVFKYAVKRSRKLAEVGSHEKVGPCCVRLEQAYLQTELC_GPSLQQHCEAHLHSQGLVHLDVKPANIFLLGDFGLL
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3P1A, Chain A