3O96 Chain A
RAC-alpha serine/threonine-protein kinase (AKT1)
Inactive — 0.1%DFG-outαC-out
Resolution
2.7 Å
R-value
0.249
Predicted activity confidence0.1%
Structure info
Alternate conformation—
Missing atoms0
Missing residues5
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
SDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFTPEEREEWTTAIQTVADGLKKQVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVANRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQV
UniProt reference sequence
FEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF
Aligned reference sequence
FEYL----------------KLLGKGT----------------FGKVILVKE--KA------------------------------------TGRYYAMKILK--KEVIVAKDE-------------------------VAHTLTENRVLQNS--------------------------RHPFLTALKYSFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSE--K------------------------------------------NVVYRDL-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGIKDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHEKLFELILME--EIRFPRTLG------------------------------------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLG--GGSED-------AKEIMQHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FEYL----------------KLLGKGT----------------FGKVILVKE--KA------------------------------------TGRYYAMKILK--KEVIVA-----------------------------------NRVLQNS--------------------------RHPFLTALKYSFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFSEDRARFYGAEIVSALDYLHSE--K------------------------------------------NVVYRDL-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHEKLFELILME--EIRFPRTLG------------------------------------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLG--GGSED-------AKEIMQHRFF
Activation segment
DFGLCKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKIL_____NRVLQNSRPFLTALKYSCFVMEYANGGELFFHLSRLHSEKNVVYRDLKLENLMLITDFGLC
Ligand info
Orthosteric ligand
None
Allosteric ligand
IQO
Ligand typeAllosteric
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3O96, Chain A