3NW7 Chain A
Insulin-like growth factor 1 receptor (IGF1R)
Inactive — 0.0%DFG-inαC-inType1 · LGV
Resolution
2.11 Å
R-value
0.168
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
YVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK
UniProt reference sequence
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
Aligned reference sequence
ITMS----------------RELGQGS----------------FGMVYEGVA--KGVVKDE-------------------------------PETRVAIKTVN--EAASMRE---------------------------RIEFLNEASVMKEF--------------------------NCHHVVRLLGVVSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVIMELMTR--------------GDLKSYLRS--LRPEMENNPVLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLSKMIQMAGEIADGMAYLNAN---------------------------------------------KFVHRDL-----AARNCMVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMSPESLKD--------------------------------GVFT-TYSDVWSFGVVLWEIATL--A--------------EQPYQG--------------------------------------------------LSNEQVLRFVMEG--GLLDKPDNCP-----------------------------------------------------------------------------------------------------DMLFELMRMCWQYNPKMRPS--------------FLEIISSIKE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITMS----------------RELGQGS----------------FGMVYEGVA--KGVVKDE-------------------------------PETRVAIKTVN--EAASMRE---------------------------RIEFLNEASVMKEF--------------------------NCHHVVRLLGVVSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVIMELMTR--------------GDLKSYLRS--LRPEMENNPVLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLSKMIQMAGEIADGMAYLNAN---------------------------------------------KFVHRDL-----AARNCMVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLLPVRWMSPESLKD--------------------------------GVFT-TYSDVWSFGVVLWEIATL--A--------------EQPYQG--------------------------------------------------LSNEQVLRFVMEG--GLLDKPDNCP-----------------------------------------------------------------------------------------------------DMLFELMRMCWQYNPKMRPS--------------FLEIISSIKE
Activation segment
DFGMTRDIYETDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLLPVRWMSPE
Binding pocket
RELGQGSFGMVYEVAIKTVEFLNEASVMKEFN_HVVRLLGVLVIMELMTRGDLKSYLRSYLNANKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
LGV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3NW7, Chain A