3NUX Chain A
Cyclin-dependent kinase 6 (CDK6)
Inactive — 0.0%DFG-inαC-outType1 · 3NV
Resolution
2.7 Å
R-value
0.243
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues1
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
DQQYECVAEIGEGAGKVFKARDLKNGGRFVALKRVRPLSTIREVAVLRHLETFEHPNVVRLFDVCTKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLAVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ
UniProt reference sequence
YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
Aligned reference sequence
YECV----------------AEIGEGA----------------YGKVFKARD--LKN-----------------------------------GGRFVALKRVR--VQTGEEGM--------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVCTVSR--TDRET-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLARIYSFQMAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TSVVVTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YECV----------------AEIGEGA-----------------GKVFKARD--LKN-----------------------------------GGRFVALKRVR------------------------------------PLSTIREVAVLRHL--ETF---------------------EHPNVVRLFDVC----------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLTLVFEHVD---------------QDLTTYLDK--VPEP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPTETIKDMMFQLLRGLDFLHSH---------------------------------------------RVVHRDL-----KPQNILVTS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQIKLADFGLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLWYRAPEVLLQ--------------------------------SSYA-TPVDLWSVGCIFAEMFRR-----------------KPLFRG--------------------------------------------------SSDVDQLGKILDV--IGLPGEEDWPRDVALPRQAFH-KSAQPIEKFVTDID---------------------------------------------------------------------------ELGKDLLLKCLTFNPAKRIS--------------AYSALSHPYF
Activation segment
DFGLA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VTLWYRAPE
Binding pocket
AEIGEGA_GKVFKVALKRVSTIREVAVLRHLEPNVVRLFDVTLVFEHVD_QDLTTYLDKFLHSHRVVHRDLKPQNILVLADFGLA
Ligand info
Orthosteric ligand
3NV
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3NUX, Chain A