3NPC Chain A
Mitogen-activated protein kinase 9 (MAPK9)
Inactive — 0.3%DFG-outαC-inType2 · B96
Resolution
2.35 Å
R-value
0.214
Predicted activity confidence0.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DNQFYSVEVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYAANVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDW
UniProt reference sequence
YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI
Aligned reference sequence
YQQL----------------KPIGSGA----------------QGIVCAAFD--TV------------------------------------LGINVAVKKLS--RPFQNQTH--------------------------AKRAYRELVLLKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELMD---------------ANLCQVIHM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFGLARTACTNFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPEVILG--------------------------------MGYK-ENVDIWSVGCIMGELVKG-----------------CVIFQG--------------------------------------------------TDHIDQWNKVIEQ--LGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKT------------------------------------------------------------SQARDLLSKMLVIDPDKRIS--------------VDEALRHPYI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YQQL----------------KPIGSGA----------------QGIVCAAFD--TV------------------------------------LGINVAVKKLS--RPFQNQTH--------------------------AKRAYRELVLLKCV--------------------------NHKNIISLLNVFTPQK--TLEEFQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DVYLVMELMD---------------ANLCQVIHM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELDHERMSYLLYQMLCGIKHLHSA---------------------------------------------GIIHRDL-----KPSNIVVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCTLKILDFGLARTACTNFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPEVILG--------------------------------MGYA-ANVDIWSVGCIMGELVKG-----------------CVIFQG--------------------------------------------------TDHIDQWNKVIEQ--LGTPSAEFMAALQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKT------------------------------------------------------------SQARDLLSKMLVIDPDKRIS--------------VDEALRHPYI
Activation segment
DFGLARTACTNFMM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPYVVTRYYRAPE
Binding pocket
KPIGSGAQGIVCAVAVKKLRAYRELVLLKCVNKNIISLLNVYLVMELMD_ANLCQVIHMHLHSAGIIHRDLKPSNIVVILDFGLA
Ligand info
Orthosteric ligand
B96
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3NPC, Chain A