3MY0 Chain X
Activin receptor type-1-like (ACVRL1)
Inactive — 15.2%DFG-inαC-inType1 · LDN
Resolution
2.65 Å
R-value
0.209
Predicted activity confidence15.2%
Structure info
Alternate conformation—
Missing atoms31
Missing residues3
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARREDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLALAQMMRECWYPNPSARLTALRIKKT
UniProt reference sequence
VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQK
Aligned reference sequence
VALV----------------ECVGKGR----------------YGEVWRGLW----------------------------------------HGESVAVKIFS--SRD-------------------------------EQSWFRETEIYNTV--LL----------------------RHDNILGFIASDMTSR--NSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEH--------------GSLYDFLQR--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEPHLALRLAVSAACGLAHLHVE--IFGTQGKP-----------------------------------AIAHRDF-----KSRNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQCCIADLGLAVMHSQGSDY--LDIGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--QIRTDC------------------------FESY-KWTDIWAFGLVLWEIARR--TIVNGIVEDY-----RPPFYD--VVPND-------------------------------------------PSFEDMKKVVCVD--QQTPTIPNRLAADPVL-----------------------------------------------------------------------------------------------SGLAQMMRECWYPNPSARLT--------------ALRIKKTLQK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VALV----------------ECVGKGR----------------YGEVWRGLW----------------------------------------HGESVAVKIFS--SRD-------------------------------EQSWFRETEIYNTV--LL----------------------RHDNILGFIASDMT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LWLITHYHEH--------------GSLYDFLQR--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEPHLALRLAVSAACGLAHLHVE--I-----KP-----------------------------------AIAHRDF-----KSRNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQCCIADLGLAVM-------------N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--QIRTDC------------------------FESY-KWTDIWAFGLVLWEIARR---------EDY-----RPPFYD--VVPND-------------------------------------------PSFEDMKKVVCVD--QQTPTIPNRLA------------------------------------------------------------------------------------------------------LAQMMRECWYPNPSARLT--------------ALRIKKT---
Activation segment
DLGLAVM-------------N-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETEIYNTVLDNILGFIASWLITHYHEHGSLYDFLQR___KPAIAHRDFKSRNVLVIADLGLA
Ligand info
Orthosteric ligand
LDN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3MY0, Chain X