3MY0 Chain J
Activin receptor type-1-like (ACVRL1)
Inactive — 2.1%DFG-inαC-inType1 · LDN
Resolution
2.65 Å
R-value
0.209
Predicted activity confidence2.1%
Structure info
Alternate conformation—
Missing atoms54
Missing residues4
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
RQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEPAIAHRDFKSRNVLVKSNLQCCIADLGLAVRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVVEDYRPPFYDVVPEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKIS
UniProt reference sequence
VALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQK
Aligned reference sequence
VALV----------------ECVGKGR----------------YGEVWRGLW----------------------------------------HGESVAVKIFS--SRD-------------------------------EQSWFRETEIYNTV--LL----------------------RHDNILGFIASDMTSR--NSST--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEH--------------GSLYDFLQR--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEPHLALRLAVSAACGLAHLHVE--IFGTQGKP-----------------------------------AIAHRDF-----KSRNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQCCIADLGLAVMHSQGSDY--LDIGN-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPRVGTKRYMAPEVLDE--QIRTDC------------------------FESY-KWTDIWAFGLVLWEIARR--TIVNGIVEDY-----RPPFYD--VVPND-------------------------------------------PSFEDMKKVVCVD--QQTPTIPNRLAADPVL-----------------------------------------------------------------------------------------------SGLAQMMRECWYPNPSARLT--------------ALRIKKTLQK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VALV----------------ECVGKGR----------------YGEVWRGLW----------------------------------------HGESVAVKIFS--SRD-------------------------------EQSWFRETEIYNTV--LL----------------------RHDNILGFIASDM-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLITHYHEH--------------GSLYDFLQR--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLEPHLALRLAVSAACGLAHLHVE---------P-----------------------------------AIAHRDF-----KSRNVLVKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLQCCIADLGLAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYMAPEVLDE--QIRTDC------------------------FESY-KWTDIWAFGLVLWEIARR--TIV---VEDY-----RPPFYD--VVP------------------------------------------------EDMKKVVCVD--QQTPTIPNRLAADPVL-----------------------------------------------------------------------------------------------SGLAQMMRECWYPNPSARLT--------------ALRIKKTLQK
Activation segment
DLGLAV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYMAPE
Binding pocket
ECVGKGRYGEVWRVAVKIFSWFRETEIYNTVLDNILGFIASWLITHYHEHGSLYDFLQR____PAIAHRDFKSRNVLVIADLGLA
Ligand info
Orthosteric ligand
LDN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3MY0, Chain J