3MTL Chain A
Cyclin-dependent kinase 16 (CDK16)
Inactive — 0.1%DFG-outαC-inType1 · FEF
Resolution
2.4 Å
R-value
0.198
Predicted activity confidence0.1%
Structure info
Alternate conformationA
Missing atoms30
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKE
UniProt reference sequence
YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF
Aligned reference sequence
YIKL----------------DKLGEGT----------------YATVYKGKS--KL------------------------------------TDNLVALKEIR--LEHEEGA---------------------------PCTAIREVSLLKDL--------------------------KHANIVTLHDIIHTEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTLVFEYLD---------------KDLKQYLDD--CGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IINMHNVKLFLFQLLRGLAYCHRQ---------------------------------------------KVLHRDL-----KPQNLLINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGELKLADFGLARAKSIPTKT--Y---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNEVVTLWYRPPDILLG--S-----------------------------TDYS-TQIDMWGVGCIFYEMATG-----------------RPLFPG--------------------------------------------------STVEEQLHFIFRI--LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLD------------------------------------------------------------------------SDGADLLTKLLQFEGRNRIS--------------AEDAMKHPFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YIKL----------------DKLGEGT----------------YATVYKGKS--KL------------------------------------TDNLVALKEIR--L---------------------------------PCTAIREVSLLKDL--------------------------KHANIVTLHDIIHTEK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLTLVFEYLD---------------KDLKQYLDD--CGN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IINMHNVKLFLFQLLRGLAYCHRQ---------------------------------------------KVLHRDL-----KPQNLLINE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGELKLADFGLARAK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRPPDILLG--S-----------------------------TDYS-TQIDMWGVGCIFYEMATG-----------------RPLFPG--------------------------------------------------STVEEQLHFIFRI--LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLD------------------------------------------------------------------------SDGADLLTKLLQFEGRNRIS--------------AEDAMKHPFF
Activation segment
DFGLARAK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLWYRPPD
Binding pocket
DKLGEGTYATVYKVALKEITAIREVSLLKDLKANIVTLHDITLVFEYLD_KDLKQYLDDYCHRQKVLHRDLKPQNLLILADFGLA
Ligand info
Orthosteric ligand
FEF
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3MTL, Chain A