3MDY Chain C
Bone morphogenetic protein receptor type-1B (BMPR1B)
Active — 61.8%DFG-inαC-inType1 · LDN
Resolution
2.05 Å
R-value
0.204
Predicted activity confidence61.8%
Structure info
Alternate conformationA
Missing atoms4
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFIIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDI
UniProt reference sequence
IQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAK
Aligned reference sequence
IQMV----------------KQIGKGR----------------YGEVWMGKW----------------------------------------RGEKVAVKVFF--TTE-------------------------------EASWFRETEIYQTV--LM----------------------RHENILGFIAADIKGT--GSWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLYLITDYHEN--------------GSLYDYLKS--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTE--IFSTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVKFISDTNE--VDIPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTRVGTKRYMPPEVLDE--SLNRNH------------------------FQSY-IMADMYSFGLILWEVARR--CVSGGIVEEY-----QLPYHD--LVPSD-------------------------------------------PSYEDMREIVCIK--KLRPSFPNRWSSDECL-----------------------------------------------------------------------------------------------RQMGKLMTECWAHNPASRLT--------------ALRVKKTLAK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IQMV----------------KQIGKGR----------------YGEVWMGKW----------------------------------------RGEKVAVKVFF--TTE-------------------------------EASWFRETEIYQTV--LM----------------------RHENILGFIAADIKGT--GSWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLYLITDYHEN--------------GSLYDYLKS--T--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDAKSMLKLAYSSVSGLCHLHTE--IFSTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVKFI---------IPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTRVGTKRYMPPEVLDE--SLNRNH------------------------FQSY-IMADMYSFGLILWEVARR--CVSGGIVEEY-----QLPYHD--LVPSD-------------------------------------------PSYEDMREIVCIK--KLRPSFPNRWSSDECL-----------------------------------------------------------------------------------------------RQMGKLMTECWAHNPASRLT--------------ALRVKKTLAK
Activation segment
DLGLAVKFI---------IPP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTRVGTKRYMPPE
Binding pocket
KQIGKGRYGEVWMVAVKVFSWFRETEIYQTVLENILGFIAAYLITDYHENGSLYDYLKSTQGKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
LDN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3MDY, Chain C