3LXN Chain A
Non-receptor tyrosine-protein kinase TYK2 (TYK2)
Active — 77.1%DFG-inαC-inType1 · MI1
Resolution
2.5 Å
R-value
0.223
Predicted activity confidence77.1%
Structure info
Alternate conformation—
Missing atoms18
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYRVGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG
UniProt reference sequence
ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTR
Aligned reference sequence
ITQL----------------SHLGQGT----------------RTNVYEGRL--RVEGSGDPEEGKMDDEDPLVPGRDRG------------QELRVVLKVLD--PSHHDI----------------------------ALAFYETASLMSQV--------------------------SHTHLAFVHGVCVRGP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ENIMVTEYVEH--------------GPLDVWLRR--ERG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HVPMAWKMVVAQQLASALSYLENK---------------------------------------------NLVHGNV-----CGRNILLAR--LGLAEGT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPFIKLSDPGVGLGALSR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EERVERIPWLAPECLPG--GA----------------------------NSLS-TAMDKWGFGATLLEICFD--G--------------EAPLQS--------------------------------------------------RSPSEKEHFYQRQ--HRLPEPSC-------------------------------------------------------------------------------------------------------PQLATLTSQCLTYEPTQRPS--------------FRTILRDLTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
DPTV----------------FHLGEGH----------------FGKVYCYDP--TNDGTGEMVAVKALKADAGPQHRSGW------------KQEIDILRTLY--HEHIIK----------------------------YKGCCEDAGAAS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LQLVMEYVPL--------------GSLRDYL----PRH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIGLAQLLLFAQQICEGMAYLHAQ---------------------------------------------HYIHRDL-----AARNVLLDN--DRL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKIGDFGVPEG---H---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYRVGDSPWYAPECL----KE----------------------------YKFY-YASDVWSFGVTLYE---L--L--------------THCDSS--------------------------------------------------QSPPTKTELLERG--ERLPRPDC-------------------------------------------------------------------------------------------------------PAEVYLMKNCWETEASFRPT--------------FKTVHEKYQG
Activation segment
DFGVPEG---H---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EYRVGDSPWYAPE
Binding pocket
RDLGEGHFGKVSLVAVKALGWKQEIDILRTLYEHIIKYKGCQLVMEYVPLGSLRDYLPRYLHAQHYIHRDLAARNVLLIGDFGLA
Ligand info
Orthosteric ligand
MI1
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3LXN, Chain A