3LW0 Chain D
Insulin-like growth factor 1 receptor (IGF1R)
Inactive — 0.0%DFG-outαC-in
Resolution
1.79 Å
R-value
0.157
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK
UniProt reference sequence
ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE
Aligned reference sequence
ITMS----------------RELGQGS----------------FGMVYEGVA--KGVVKDE-------------------------------PETRVAIKTVN--EAASMRE---------------------------RIEFLNEASVMKEF--------------------------NCHHVVRLLGVVSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVIMELMTR--------------GDLKSYLRS--LRPEMENNPVLA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLSKMIQMAGEIADGMAYLNAN---------------------------------------------KFVHRDL-----AARNCMVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKGLLPVRWMSPESLKD--------------------------------GVFT-TYSDVWSFGVVLWEIATL--A--------------EQPYQG--------------------------------------------------LSNEQVLRFVMEG--GLLDKPDNCP-----------------------------------------------------------------------------------------------------DMLFELMRMCWQYNPKMRPS--------------FLEIISSIKE
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITMS----------------RELGQGS----------------FGMVYEGVA--KGVVKDE-------------------------------PETRVAIKTVN--EAASMRE---------------------------RIEFLNEASVMKEF--------------------------NCHHVVRLLGVVSQGQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTLVIMELMTR--------------GDLKSYLRS--LRP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPSLSKMIQMAGEIADGMAYLNAN---------------------------------------------KFVHRDL-----AARNCMVAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTVKIGDFGMTRDIYETDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLLPVRWMSPESLKD--------------------------------GVFT-TYSDVWSFGVVLWEIATL--A--------------EQPYQG--------------------------------------------------LSNEQVLRFVMEG--GLLDKPDNCP-----------------------------------------------------------------------------------------------------DMLFELMRMCWQYNPKMRPS--------------FLEIISSIKE
Activation segment
DFGMTRDIYETDYY--R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGLLPVRWMSPE
Binding pocket
RELGQGSFGMVYEVAIKTVEFLNEASVMKEFN_HVVRLLGVLVIMELMTRGDLKSYLRSYLNANKFVHRDLAARNCMVIGDFGMT
Ligand info
Orthosteric ligand
None
Allosteric ligand
CCX
Ligand typeType3,Allosteric
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3LW0, Chain D