3L9P Chain A
ALK tyrosine kinase receptor (ALK)
Inactive — 31.5%DFG-inαC-in
Resolution
1.8 Å
R-value
0.192
Predicted activity confidence31.5%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
NPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAGYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIE
UniProt reference sequence
ITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEY
Aligned reference sequence
ITLI----------------RGLGHGA----------------FGEVYEGQV--SGMPNDP-------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRASYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
ITLI----------------RGLGHGA----------------FGEVYEGQV--SG------------------------------------SPLQVAVKTLP--EVCSEQD---------------------------ELDFLMEALIISKF--------------------------NHQNIVRCIGVSLQSL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PRFILLELMAG--------------GDLKSFLRE--TRPRPSQPS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAMLDLLHVARDIACGCQYLEEN---------------------------------------------HFIHRDI-----AARNCLLTC--PGP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GRVAKIGDFGMARDIYRAGYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPEAFME--------------------------------GIFT-SKTDTWSFGVLLWEIFSL--G--------------YMPYPS--------------------------------------------------KSNQEVLEFVTSG--GRMDPPKNCP-----------------------------------------------------------------------------------------------------GPVYRIMTQCWQHQPEDRPN--------------FAIILERIEY
Activation segment
DFGMARDIYRAGYY--RKG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GCAMLPVKWMPPE
Binding pocket
RGLGHGAFGEVYEVAVKTLDFLMEALIISKFNQNIVRCIGVFILLELMAGGDLKSFLREYLEENHFIHRDIAARNCLLIGDFGMA
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3L9P, Chain A