3KUL Chain B
Ephrin type-A receptor 8 (EPHA8)
Active — 96.4%DFG-inαC-in
Resolution
2.15 Å
R-value
0.19
Predicted activity confidence96.4%
Structure info
Alternate conformationA
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAATTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDALIRSP
UniProt reference sequence
IHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQIVSVLDA
Aligned reference sequence
IHIE----------------KIIGSGD----------------SGEVCYGRL--RVPGQ---------------------------------RDVPVAIKALK--AGYTERQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTRGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAMIVTEYMEN--------------GSLDTFLRT--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTIMQLVGMLRGVGAGMRYLSDL---------------------------------------------GYVHRDL-----AARNVLVDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPDA--AYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGGKIPIRWTAPEAIAF--------------------------------RTFS-SASDVWSFGVVMWEVLAY--G--------------ERPYWN--------------------------------------------------MTNRDVISSVEEG--YRLPAPMGCP-----------------------------------------------------------------------------------------------------HALHQLMLDCWHKDRAQRPR--------------FSQIVSVLDA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IHIE----------------KIIGSGD----------------SGEVCYGRL--RVPGQ---------------------------------RDVPVAIKALK--AGYTERQ---------------------------RRDFLSEASIMGQF--------------------------DHPNIIRLEGVVTRGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAMIVTEYMEN--------------GSLDTFLRT--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTIMQLVGMLRGVGAGMRYLSDL---------------------------------------------GYVHRDL-----AARNVLVDS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVLEDDPDA--A--T------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGGKIPIRWTAPEAIAF--------------------------------RTFS-SASDVWSFGVVMWEVLAY--G--------------ERPYWN--------------------------------------------------MTNRDVISSVEEG--YRLPAPMGCP-----------------------------------------------------------------------------------------------------HALHQLMLDCWHKDRAQRPR--------------FSQIVSVLDA
Activation segment
DFGLSRVLEDDPDA--A--T------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGGKIPIRWTAPE
Binding pocket
KIIGSGDSGEVCYVAIKALDFLSEASIMGQFDPNIIRLEGVMIVTEYMENGSLDTFLRTYLSDLGYVHRDLAARNVLVVSDFGLS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3KUL, Chain B