3KMU Chain A
Scaffold protein ILK (ILK)
Inactive — 0.9%DFG-outαC-out
Resolution
1.8 Å
R-value
0.202
Predicted activity confidence0.9%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
HSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWPYGSLYNVLHEGTNFVVDQSQAVKFALDARGAFLHTLEPLIPRHALNSRSVIDEDTARISADVKFSFQSPGRYAPAWVAPEALQKKPEDTNRRSADWSFAVLLWELVTREVPFADLSNEIGKVALEGLRPTIPPGISPHVSKLKICNEDPAKRPKFDIVPILEKQD
UniProt reference sequence
LNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEK
Aligned reference sequence
LNFL----------------TKLNENH----------------SGELWKGRW----------------------------------------QGNDIVVKVLK--VRDWSTRK--------------------------SRDFNEECPRLRIF--------------------------SHPNVLPVLGACQSPP--AP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPTLITHWMPY--------------GSLYNVLHE--GTNF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDQSQAVKFALDMARGMAFLHTL--EP-----------------------------------------LIPRHAL-----NSRSVMIDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DMTARISMADVKFSFQC----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGRMYAPAWVAPEALQK--KPE---------------------------DTNR-RSADMWSFAVLLWELVTR-----------------EVPFAD--------------------------------------------------LSNMEIGMKVALE--GLRPTIPPGIS----------------------------------------------------------------------------------------------------PHVCKLMKICMNEDPAKRPK--------------FDMIVPILEK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LNFL----------------TKLNENH----------------SGELWKGRW----------------------------------------QGNDIVVKVLK--VRDWSTRK--------------------------SRDFNEECPRLRIF--------------------------SHPNVLPVLGACQSPP--AP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HPTLITHW-PY--------------GSLYNVLHE--GTNF-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VVDQSQAVKFALD-ARG-AFLHTL--EP-----------------------------------------LIPRHAL-----NSRSV-IDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------D-TARIS-ADVKFSFQS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGR-YAPAWVAPEALQK--KPE---------------------------DTNR-RSAD-WSFAVLLWELVTR-----------------EVPFAD--------------------------------------------------LSN-EIG-KVALE--GLRPTIPPGIS----------------------------------------------------------------------------------------------------PHVSKL-KIC-NEDPAKRPK--------------FD-IVPILEK
Activation segment
-ADVKFSFQS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGR-YAPAWVAPE
Binding pocket
TKLNENHSGELWKIVVKVLDFNEECPRLRIFSPNVLPVLGATLITHWMPYGSLYNVLHEHTLEPLIPRHALNSRSVMIISMADVK
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3KMU, Chain A