3KEX Chain A
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Inactive — 2.3%DFG-inαC-outATPlike · ANP
Resolution
2.8 Å
R-value
0.243
Predicted activity confidence2.3%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-na
Sequence info
PDB sequence
KVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRESGPGIAPGPEPHG
UniProt reference sequence
LRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTR
Aligned reference sequence
LRKL----------------KVLGSGV----------------FGTVHKGVW--IPEGES--------------------------------IKIPVCIKVIE--DKSGRQS---------------------------FQAVTDHMLAIGSL--------------------------DHAHIVRLLGLCPGS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLQLVTQYLPL--------------GSLLDHVRQ--HRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALGPQLLLNWGVQIAKGMYYLEEH---------------------------------------------GMVHRNL-----AARNVLLKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSQVQVADFGVADLLPPDDKQ--LLY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SEAKTPIKWMALESIHF--------------------------------GKYT-HQSDVWSYGVTVWELMTF--G--------------AEPYAG--------------------------------------------------LRLAEVPDLLEKG--ERLAQPQICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDENIRPT--------------FKELANEFTR
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LRKL----------------KVLGSGV----------------FGTVHKGVW--IPEGES--------------------------------IKIPVCIKVIE--DKSGRQS---------------------------FQAVTDHMLAIGSL--------------------------DHAHIVRLLGLCPGS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLQLVTQYLPL--------------GSLLDHVRQ--HRG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALGPQLLLNWGVQIAKGMYYLEEH---------------------------------------------GMVHRNL-----AARNVLLKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PSQVQVADFGVADLLPPDDKQ--LL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPIKWMALESIHF--------------------------------GKYT-HQSDVWSYGVTVWELMTF--G--------------AEPYAG--------------------------------------------------LRLAEVPDLLEKG--ERLAQPQICT-----------------------------------------------------------------------------------------------------IDVYMVMVKCWMIDENIRPT--------------FKELANEFTR
Activation segment
DFGVADLLPPDDKQ--LL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TPIKWMALE
Binding pocket
KVLGSGVFGTVHKVCIKVIAVTDHMLAIGSLDAHIVRLLGLQLVTQYLPLGSLLDHVRQYLEEHGMVHRNLAARNVLLVADFGVA
Ligand info
Orthosteric ligand
ANP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3KEX, Chain A