3K2L Chain A
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)
Inactive — 48.7%DFG-inαC-in
Resolution
2.36 Å
R-value
0.228
Predicted activity confidence48.7%
Structure info
Alternate conformationB
Missing atoms38
Missing residues1
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
VDLGTENLYFMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPQKLLDASKRAKNFVSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP
UniProt reference sequence
YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL
Aligned reference sequence
YEVL----------------KVIGKGS----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDL-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTYIQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YEVL----------------KVIGKG-----------------FGQVVKAYD--HK------------------------------------VHQHVALKMVR--NEKRF-----------------------------HRQAAEEIRILEHL--RKQDKD------------------NTMNVIHMLENFTFRN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HICMTFELLS---------------MNLYELIKK--NKFQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFSLPLVRKFAHSILQCLDALHKN---------------------------------------------RIIHCDL-----KPENILLKQ--QG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSGIKVIDFGSSCYEHQRV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIQSRFYRAPEVILG--------------------------------ARYG-MPIDMWSLGCILAELLTG-----------------YPLLPG--------------------------------------------------EDEGDQLACMIEL--LGMP-QKLLDASKRAKNFV-SKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD-------------------------------------------PLFLDFLKQCLEWDPAVRMT--------------PGQALRHPWL
Activation segment
DFGSSCYEHQRV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YIQSRFYRAPE
Binding pocket
KVIGKG_FGQVVKVALKMVQAAEEIRILEHLRMNVIHMLENCMTFELLS_MNLYELIKKALHKNRIIHCDLKPENILLVIDFGSS
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3K2L, Chain A