3I6U Chain B
Serine/threonine-protein kinase Chk2 (CHEK2)
Inactive — 0.0%DFG-inαC-out
Resolution
3.0 Å
R-value
0.247
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues3
Salt bridge (KinCore)Saltbr-none
Sequence info
PDB sequence
TPAPWARLWALQDGFANLECVNDNYWFGRDKSCEYCFDEPLLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGLNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFPTYLAPEVLVNRAVDCWSLGVILFICLSGYPPFSEVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSE
UniProt reference sequence
YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL
Aligned reference sequence
YIMS----------------KTLGSGA----------------CGEVKLAFE--RK------------------------------------TCKKVAIKIIS--KRKFAIGSAREADP--------------------ALNVETEIEILKKL--------------------------NHPCIIKIKNFFDAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYYIVLELMEG--------------GELFDKVVG--NK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLKEATCKLYFYQMLLAVQYLHEN---------------------------------------------GIIHRDL-----KPENVLLSS--QEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCLIKITDFGHSKILGETSLM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RTLCGTPTYLAPEVLVS--VGT---------------------------AGYN-RAVDCWSLGVILFICLSG-----------------YPPFSE--H-----------------------------------------------RTQVSLKDQITSG--KYNFIPEVWAEVS--------------------------------------------------------------------------------------------------EKALDLVKKLLVVDPKARFT--------------TEEALRHPWL
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YIMS----------------KTLGSGA----------------CGEVKLAFE--RK------------------------------------TCKKVAIRIIS--KRKFAIG----------------------------LNVETEIEILKKL--------------------------NHPCIIKIKNFFDAE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DYYIVLELMEG--------------GELFDKVVG--NK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLKEATCKLYFYQMLLAVQYLHEN---------------------------------------------GIIHRDL-----KPENVLLSS--QEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCLIKITDF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTYLAPEVLV------------------------------------N-RAVDCWSLGVILFICLSG-----------------YPPFSE-----------------------------------------------------VSLKDQITSG--KYNFIPEVWAEVS--------------------------------------------------------------------------------------------------EKALDLVKKLLVVDPKARFT--------------TEEALRHPWL
Activation segment
DF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTYLAPE
Binding pocket
KTLGSGACGEVKLVAIRIINVETEIEILKKLNPCIIKIKNFYIVLELMEGGELFDKVVGYLHENGIIHRDLKPENVLLITDF___
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3I6U, Chain B