3HNG Chain A
Vascular endothelial growth factor receptor 1 (FLT1)
Inactive — 0.0%DFG-outαC-inType2 · 8ST
Resolution
2.7 Å
R-value
0.197
Predicted activity confidence0.0%
Structure info
Alternate conformationB
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
EVPLDEQCERPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL
UniProt reference sequence
LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD
Aligned reference sequence
LKLG----------------KSLGRGA----------------FGKVVQASA--FGIKKSP-------------------------------TCRTVAVKMLK--EGATASE---------------------------YKALMTELKILTHI--G-----------------------HHLNVVNLLGACTKQG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVIVEYCKY--------------GNLSNYLKS--KRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PITMEDLISYSFQVARGMEFLSSR---------------------------------------------KCIHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVVKICDFGLARDIYKNPDY--VRK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GDTRLPLKWMAPESIFD--------------------------------KIYS-TKSDVWSYGVLLWEIFSL--G--------------GSPYPG--V-----------------------------------------------QMDEDFCSRLREG--MRMRAPEYST-----------------------------------------------------------------------------------------------------PEIYQIMLDCWHRDPKERPR--------------FAELVEKLGD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLG----------------KSLGRGA----------------FGKVVQASA--FGIKKSP-------------------------------TCRTVAVKMLK--EGATASE---------------------------YKALMTELKILTHI--G-----------------------HHLNVVNLLGACTKQG--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PLMVIVEYCKY--------------GNLSNYLKS--KR-----------------------------------------------------------------KE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PITMEDLISYSFQVARGMEFLSSR---------------------------------------------KCIHRDL-----AARNILLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NNVVKICDFGLARDIYKNPDY--VRK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRLPLKWMAPESIFD--------------------------------KIYS-TKSDVWSYGVLLWEIFSL--G--------------GSPYPG--V-----------------------------------------------QMDEDFCSRLREG--MRMRAPEYST-----------------------------------------------------------------------------------------------------PEIYQIMLDCWHRDPKERPR--------------FAELVEKLGD
Activation segment
DFGLARDIYKNPDY--VRK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRLPLKWMAPE
Binding pocket
KSLGRGAFGKVVQVAVKMLALMTELKILTHIGLNVVNLLGAMVIVEYCKYGNLSNYLKSFLSSRKCIHRDLAARNILLICDFGLA
Ligand info
Orthosteric ligand
8ST
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3HNG, Chain A