3GP0 Chain A
Mitogen-activated protein kinase 11 (MAPK11)
Inactive — 0.3%DFG-outαC-inType2 · NIL
Resolution
1.9 Å
R-value
0.181
Predicted activity confidence0.3%
Structure info
Alternate conformationA
Missing atoms8
Missing residues7
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
MRAGFYRQELNKTVWEVPQRLQGLRPVGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGEEMGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSF
UniProt reference sequence
LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
Aligned reference sequence
LQGL----------------RPVGSGA----------------YGSVCSAYD--AR------------------------------------LRQKVAVKKLS--RPFQSLIH--------------------------ARRTYRELRLLKHL--------------------------KHENVIGLLDVFTPAT--SIEDFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVYLVTTLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALSDEHVQFLVYQLLRGLKYIHSA---------------------------------------------GIIHRDL-----KPSNVAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELRILDFGLARQADEEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLQG-----------------KALFPG--------------------------------------------------SDYIDQLKRIMEV--VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----------------------------------------------------------------------PLAIDLLGRMLVLDSDQRVS--------------AAEALAHAYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQGL----------------RPV---------------------GSVCSAYD--AR------------------------------------LRQKVAVKKLS--RPFQSLIH--------------------------ARRTYRELRLLKHL--------------------------KHENVIGLLDVFTPAT--SIEDFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVYLVTTLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALSDEHVQFLVYQLLRGLKYIHSA---------------------------------------------GIIHRDL-----KPSNVAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELRILDFG------EEM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLQG-----------------KALFPG--------------------------------------------------SDYIDQLKRIMEV--VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----------------------------------------------------------------------PLAIDLLGRMLVLDSDQRVS--------------AAEALAHAYF
Activation segment
DFG------EEM---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GYVATRWYRAPE
Binding pocket
RPVGS_____VCSVAVKKLRTYRELRLLKHLKENVIGLLDVYLVTTLMG_ADLNNIVKCYIHSAGIIHRDLKPSNVAVILDFG__
Ligand info
Orthosteric ligand
NIL
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3GP0, Chain A