3GGF Chain B
Serine/threonine-protein kinase 26 (STK26)
Inactive — 0.1%DFG-outαC-outType1 · GVD
Resolution
2.35 Å
R-value
0.222
Predicted activity confidence0.1%
Structure info
Alternate conformationB
Missing atoms15
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
ADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVANTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTSYLTELIDRFKRWKAE
UniProt reference sequence
FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI
Aligned reference sequence
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVAGQLTDTQIK--R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FTKL----------------ERIGKGS----------------FGEVFKGID--NR------------------------------------TQQVVAIKIID--LEEAEDE---------------------------IEDIQQEITVLSQC--------------------------DSSYVTKYYGSYLKGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLWIIMEYLGG--------------GSALDLLRA--G--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PFDEFQIATMLKEILKGLDYLHSE---------------------------------------------KKIHRDI-----KAANVLLSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGDVKLADFGVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPEVIQQ--------------------------------SAYD-SKADIWSLGITAIELAKG-----------------EPPNSD--------------------------------------------------MHPMRVLFLIPKN--NPPTLVGDFT-----------------------------------------------------------------------------------------------------KSFKEFIDACLNKDPSFRPT--------------AKELLKHKFI
Activation segment
DFGVA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NTFVGTPFWMAPE
Binding pocket
ERIGKGSFGEVFKVAIKIIDIQQEITVLSQCDSYVTKYYGSWIIMEYLGGGSALDLLRAYLHSEKKIHRDIKAANVLLLADFGVA
Ligand info
Orthosteric ligand
GVD
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3GGF, Chain B