3GC8 Chain B
Mitogen-activated protein kinase 11 (MAPK11)
Inactive — 0.0%DFG-inαC-inType1 · B45
Resolution
2.4 Å
R-value
0.212
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
PRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFK
UniProt reference sequence
LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
Aligned reference sequence
LQGL----------------RPVGSGA----------------YGSVCSAYD--AR------------------------------------LRQKVAVKKLS--RPFQSLIH--------------------------ARRTYRELRLLKHL--------------------------KHENVIGLLDVFTPAT--SIEDFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVYLVTTLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALSDEHVQFLVYQLLRGLKYIHSA---------------------------------------------GIIHRDL-----KPSNVAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DCELRILDFGLARQADEEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLQG-----------------KALFPG--------------------------------------------------SDYIDQLKRIMEV--VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----------------------------------------------------------------------PLAIDLLGRMLVLDSDQRVS--------------AAEALAHAYF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LQGL----------------RPVGSGA----------------YGSVCSAYD--AR------------------------------------LRQKVAVKKLS--RPFQSLIH--------------------------ARRTYRELRLLKHL--------------------------KHENVIGLLDVFTPAT--SIEDFS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EVYLVTTLMG---------------ADLNNIVKC--Q--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALSDEHVQFLVYQLLRGLKYIHSA---------------------------------------------GIIHRDL-----KPSNVAVNE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSELRILDFGLARQADEEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPEIMLN--W-----------------------------MHYN-QTVDIWSVGCIMAELLQG-----------------KALFPG--------------------------------------------------SDYIDQLKRIMEV--VGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGAN-----------------------------------------------------------------------PLAIDLLGRMLVLDSDQRVS--------------AAEALAHAYF
Activation segment
DFGLARQADEEM--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGYVATRWYRAPE
Binding pocket
RPVGSGAYGSVCSVAVKKLRTYRELRLLKHLKENVIGLLDVYLVTTLMG_ADLNNIVKCYIHSAGIIHRDLKPSNVAVILDFGLA
Ligand info
Orthosteric ligand
B45
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3GC8, Chain B