3FZR Chain A
Protein-tyrosine kinase 2-beta (PTK2B)
Inactive — 0.0%DFG-outαC-inType1 · 3JZ
Resolution
2.7 Å
R-value
0.214
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
GIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAM
UniProt reference sequence
VVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSD
Aligned reference sequence
VVLN----------------RILGEGF----------------FGEVYEGVY--TNHKG---------------------------------EKINVAVKTCK--KDCTLDN---------------------------KEKFMSEAVIMKNL--------------------------DHPHIVKLIGIIEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTWIIMELYPY--------------GELGHYLER--NKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLKVLTLVLYSLQICKAMAYLESI---------------------------------------------NCVHRDI-----AVRNILVAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PECVKLGDFGLSRYIEDEDYY--KA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SVTRLPIKWMSPESINF--------------------------------RRFT-TASDVWMFAVCMWEILSF--G--------------KQPFFW--------------------------------------------------LENKDVIGVLEKG--DRLPKPDLCP-----------------------------------------------------------------------------------------------------PVLYTLMTRCWDYDPSDRPR--------------FTELVCSLSD
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
VVLN----------------RILGEGF----------------FGEVYEGVY--TNHKG---------------------------------EKINVAVKTCK--KDCTLDN---------------------------KEKFMSEAVIMKNL--------------------------DHPHIVKLIGIIEEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PTWIIMELYPY--------------GELGHYLER--NKN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLKVLTLVLYSLQICKAMAYLESI---------------------------------------------NCVHRDI-----AVRNILVAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PECVKLGDFGLSR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRLPIKWMSPESINF--------------------------------RRFT-TASDVWMFAVCMWEILSF--G--------------KQPFFW--------------------------------------------------LENKDVIGVLEKG--DRLPKPDLCP-----------------------------------------------------------------------------------------------------PVLYTLMTRCWDYDPSDRPR--------------FTELVCSLSD
Activation segment
DFGLSR----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TRLPIKWMSPE
Binding pocket
RILGEGFFGEVYEVAVKTCKFMSEAVIMKNLDPHIVKLIGIWIIMELYPYGELGHYLERYLESINCVHRDIAVRNILVLGDFGLS
Ligand info
Orthosteric ligand
3JZ
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3FZR, Chain A