3FAA Chain A
TGF-beta receptor type-1 (TGFBR1)
Active — 99.0%DFG-inαC-inType1 · 55F
Resolution
3.35 Å
R-value
0.228
Predicted activity confidence99.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
ISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDINHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG
UniProt reference sequence
IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQ
Aligned reference sequence
IVLQ----------------ESIGKGR----------------FGEVWRGKW----------------------------------------RGEEVAVKIFS--SRE-------------------------------ERSWFREAEIYQTV--ML----------------------RHENILGFIAADNKDN--GTWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVSDYHEH--------------GSLFDYLNR--Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHME--IVGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVRHDSATDT--IDIAP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPEVLDD--SINMKH------------------------FESF-KRADIYAMGLVFWEIARR--CSIGGIHEDY-----QLPYYD--LVPSD-------------------------------------------PSVEEMRKVVCEQ--KLRPNIPNRWQSCEAL-----------------------------------------------------------------------------------------------RVMAKIMRECWYANGAARLT--------------ALRIKKTLSQ
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IVLQ----------------ESIGKGR----------------FGEVWRGKW----------------------------------------RGEEVAVKIFS--SRE-------------------------------ERSWFREAEIYQTV--ML----------------------RHENILGFIAADNKDN--GTWT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLWLVSDYHEH--------------GSLFDYLNR--Y--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TVTVEGMIKLALSTASGLAHLHME--IVGTQGKP-----------------------------------AIAHRDL-----KSKNILVKK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGTCCIADLGLAVRHDSATDT--IDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPEVLDD--SINMKH------------------------FESF-KRADIYAMGLVFWEIARR--CSIGGIHEDY-----QLPYYD--LVPSD-------------------------------------------PSVEEMRKVVCEQ--KLRPNIPNRWQSCEAL-----------------------------------------------------------------------------------------------RVMAKIMRECWYANGAARLT--------------ALRIKKTLSQ
Activation segment
DLGLAVRHDSATDT--IDI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NHRVGTKRYMAPE
Binding pocket
ESIGKGRFGEVWRVAVKIFSWFREAEIYQTVMENILGFIAAWLVSDYHEHGSLFDYLNRTQGKPAIAHRDLKSKNILVIADLGLA
Ligand info
Orthosteric ligand
55F
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3FAA, Chain A