3F82 Chain A
Hepatocyte growth factor receptor (MET)
Inactive — 0.0%DFG-outαC-inType2 · 353
Resolution
2.5 Å
R-value
0.183
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLKIHCAVKSLNRGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVK
UniProt reference sequence
LIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISA
Aligned reference sequence
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--LDNDG---------------------------------KKIHCAVKSLN--RITDIGE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKYLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFGLARDMYDKEYY--SVHNK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGAKLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LIVH--FN------------EVIGRGH----------------FGCVYHGTL--L--------------------------------------KIHCAVKSLN--R----GE---------------------------VSQFLTEGIIMKDF--------------------------SHPNVLSLLGICLRSE--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPLVVLPYMKH--------------GDLRNFIRN--ETH------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NPTVKDLIGFGLQVAKGMKFLASK---------------------------------------------KFVHRDL-----AARNCMLDE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFTVKVADFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWMALESLQT--------------------------------QKFT-TKSDVWSFGVLLWELMTR--G--------------APPYPD--------------------------------------------------VNTFDITVYLLQG--RRLLQPEYCP-----------------------------------------------------------------------------------------------------DPLYEVMLKCWHPKAEMRPS--------------FSELVSRISA
Activation segment
DFG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWMALE
Binding pocket
EVIGRGHFGCVYHCAVKSLQFLTEGIIMKDFSPNVLSLLGILVVLPYMKHGDLRNFIRNFLASKKFVHRDLAARNCMLVADFG__
Ligand info
Orthosteric ligand
353
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3F82, Chain A