3E8D Chain A
RAC-beta serine/threonine-protein kinase (AKT2)
Active — 99.6%DFG-inαC-inType1.5_Back · G98
Resolution
2.7 Å
R-value
0.214
Predicted activity confidence99.6%
Structure info
Alternate conformationA
Missing atoms6
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
KVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITHFPQFDYSASIR
UniProt reference sequence
FDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF
Aligned reference sequence
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTFCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDYL----------------KLLGKGT----------------FGKVILVRE--KA------------------------------------TGRYYAMKILR--KEVIIAKDE-------------------------VAHTVTESRVLQNT--------------------------RHPFLTALKYAFQTHD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLCFVMEYANG--------------GELFFHLSR--ER-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VFTEERARFYGAEIVSALEYLHSR---------------------------------------------DVVYRDI-----KLENLMLDK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGHIKITDFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-FCGTPEYLAPEVLED--------------------------------NDYG-RAVDWWGLGVVMYEMMCG-----------------RLPFYN--------------------------------------------------QDHERLFELILME--EIRFPRTLS------------------------------------------------------------------------------------------------------PEAKSLLAGLLKKDPKQRLG--GGPSD-------AKEVMEHRFF
Activation segment
DFGLCKEGISDGAT--M---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-FCGTPEYLAPE
Binding pocket
KLLGKGTFGKVILYAMKILHTVTESRVLQNTRPFLTALKYACFVMEYANGGELFFHLSRYLHSRDVVYRDIKLENLMLITDFGLC
Ligand info
Orthosteric ligand
G98
Allosteric ligand
None
Ligand typeType1.5_Back
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3E8D, Chain A