3DTC Chain A
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9)
Inactive — 0.0%DFG-inαC-outType1 · VIN
Resolution
2.6 Å
R-value
0.221
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
LLEIDFAELTLEEIIGIGGFGKVYRAFWIGDEVAVKAATIENVRQEAKLFAMLKHPNIIALRGVCLKELCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTT
UniProt reference sequence
LTLEEIIGIGGFGKVYRAFWIGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTT
Aligned reference sequence
LTLE----------------EIIGIGG----------------FGKVYRAFW----------------------------------------IGDEVAVKAAR--HDPDEDISQT------------------------IENVRQEAKLFAML--------------------------KHPNIIALRGVCLKEP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLCLVMEFARG--------------GPLNRVLSG--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHDE--AIV----------------------------------------PIIHRDL-----KSSNILILQ--KVENGDLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKILKITDFGLAREWHRTTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSAAGTYAWMAPEVIRA--------------------------------SMFS-KGSDVWSYGVLLWELLTG-----------------EVPFRG--------------------------------------------------IDGLAVAYGVAMN--KLALPIPSTCP----------------------------------------------------------------------------------------------------EPFAKLMEDCWNPDPHSRPS--------------FTNILDQLTT
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LTLE----------------EIIGIGG----------------FGKVYRAFW----------------------------------------IGDEVAVKAA------------T------------------------IENVRQEAKLFAML--------------------------KHPNIIALRGVCLKE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LCLVMEFARG--------------GPLNRVLSG--K--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RIPPDILVNWAVQIARGMNYLHDE--AIV----------------------------------------PIIHRDL-----KSSNILILQ--KVENGDLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKILKITDFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAYAWMAPEVIRA--------------------------------SMFS-KGSDVWSYGVLLWELLTG-----------------EVPFRG--------------------------------------------------IDGLAVAYGVAMN--KLALPIPSTCP----------------------------------------------------------------------------------------------------EPFAKLMEDCWNPDPHSRPS--------------FTNILDQLTT
Activation segment
DFGL--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAYAWMAPE
Binding pocket
EIIGIGGFGKVYRVAVKAANVRQEAKLFAMLKPNIIALRGVCLVMEFARGGPLNRVLSGDEAIVPIIHRDLKSSNILIITDFGLG
Ligand info
Orthosteric ligand
VIN
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationout
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3DTC, Chain A