3DLS Chain A
PAS domain-containing serine/threonine-protein kinase (PASK)
Active — 100.0%DFG-inαC-inATPlike · ADP
Resolution
2.3 Å
R-value
0.244
Predicted activity confidence100.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
AVELEGLAACEGEYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQPVNLADYTWEEVF
UniProt reference sequence
YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWV
Aligned reference sequence
YSTM----------------SPLGSGA----------------FGFVWTAVD--KE------------------------------------KNKEVVVKFIK--KEKVLEDCWIEDPK--------------------LGKVTLEIAILSRV--------------------------EHANIIKVLDIFENQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFQLVMEKHGS--G-----------LDLFAFIDR--HP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEPLASYIFRQLVSAVGYLRLK---------------------------------------------DIIHRDI-----KDENIVIAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTIKLIDFGSAAYLERGKLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTFCGTIEYCAPEVLMG--------------------------------NPYRGPELEMWSLGVTLYTLVFE-----------------ENPFC--------------------------------------------------------ELEETVEA--AIHPPYLVS------------------------------------------------------------------------------------------------------KELMSLVSGLLQPVPERRTT--------------LEKLVTDPWV
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
YSTM----------------SPLGSGA----------------FGFVWTAVD--KE------------------------------------KNKEVVVKFIK--KEKVLEDCWIEDPK--------------------LGKVTLEIAILSRV--------------------------EHANIIKVLDIFENQG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FFQLVMEKHGS--G-----------LDLFAFIDR--HP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RLDEPLASYIFRQLVSAVGYLRLK---------------------------------------------DIIHRDI-----KDENIVIAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DFTIKLIDFGSAAYLERGKLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTFCGTIEYCAPEVLMG--------------------------------NPYRGPELEMWSLGVTLYTLVFE-----------------ENPFC--------------------------------------------------------ELEETVEA--AIHPPYLVS------------------------------------------------------------------------------------------------------KELMSLVSGLLQPVPERRTT--------------LEKLVTDPWV
Activation segment
DFGSAAYLERGKLF------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YTFCGTIEYCAPE
Binding pocket
SPLGSGAFGFVWTVVVKFIKVTLEIAILSRVEANIIKVLDIQLVMEKHGSGLDLFAFIDYLRLKDIIHRDIKDENIVILIDFGSA
Ligand info
Orthosteric ligand
ADP
Allosteric ligand
None
Ligand typeATPlike
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3DLS, Chain A