3DKO Chain A
Ephrin type-A receptor 7 (EPHA7)
Inactive — 0.0%DFG-outαC-inType2 · IHZ
Resolution
2.0 Å
R-value
0.191
Predicted activity confidence0.0%
Structure info
Alternate conformationA
Missing atoms7
Missing residues3
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
TYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSAHH
UniProt reference sequence
IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDK
Aligned reference sequence
IKIE----------------RVIGAGE----------------FGEVCSGRL--KLPGK---------------------------------RDVAVAIKTLK--VGYTEKQ---------------------------RRDFLCEASIMGQF--------------------------DHPNVVHLEGVVTRGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVIEFMEN--------------GALDAFLRK--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMRYLADM---------------------------------------------GYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFGLSRVIEDDPEA--VYTT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TGGKIPVRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPAPMDCP-----------------------------------------------------------------------------------------------------AGLHQLMLDCWQKERAERPK--------------FEQIVGILDK
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
IKIE----------------RVIGA-E----------------FGEVCSGRL--KLPGK---------------------------------RDVAVAIKTLK--VGYTEKQ---------------------------RRDFLCEASIMGQF--------------------------DHPNVVHLEGVVTRGK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVMIVIEFMEN--------------GALDAFLRK--HDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFTVIQLVGMLRGIAAGMRYLADM---------------------------------------------GYVHRDL-----AARNILVNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NLVCKVSDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVRWTAPEAIQY--------------------------------RKFT-SASDVWSYGIVMWEVMSY--G--------------ERPYWD--------------------------------------------------MSNQDVIKAIEEG--YRLPAPMDCP-----------------------------------------------------------------------------------------------------AGLHQLMLDCWQKERAERPK--------------FEQIVGILDK
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVRWTAPE
Binding pocket
RVIGA_EFGEVCSVAIKTLDFLCEASIMGQFDPNVVHLEGVMIVIEFMENGALDAFLRKYLADMGYVHRDLAARNILVVSDFG__
Ligand info
Orthosteric ligand
IHZ
Allosteric ligand
None
Ligand typeType2
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3DKO, Chain A