3DAJ Chain A
Aurora kinase A (AURKA)
Inactive — 0.0%DFG-outαC-inType1 · FXG
Resolution
2.0 Å
R-value
0.253
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms14
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
QWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSTLDYLPPEMIHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSS
UniProt reference sequence
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVHAPSSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLCGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDIG----------------RPLGKGK----------------FGNVYLARE--RQ------------------------------------SKFILALKVLF--KTQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGELKIADFGWS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDYLPPEMI------------------------------------HD-EKVDLWSLGVLCYEFLVG-----------------MPPFEA--------------------------------------------------HTYQETYRRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNASQRLT--------------LAEVLEHPWI
Activation segment
DFGWS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLDYLPPE
Binding pocket
RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS
Ligand info
Orthosteric ligand
FXG
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationout
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3DAJ, Chain A