3D7U Chain A
Tyrosine-protein kinase CSK (CSK)
Active — 89.7%DFG-inαC-in
Resolution
4.11 Å
R-value
0.294
Predicted activity confidence89.7%
Structure info
Alternate conformation—
Missing atoms0
Missing residues0
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
UniProt reference sequence
LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH
Aligned reference sequence
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--NDAT------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEEK--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFGLTKEASSTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTGKLPVKWTAPEALRE--------------------------------KKFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--NDAT------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEEK--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFGLTKEAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWTAPEALRE--------------------------------KKFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Activation segment
DFGLTKEAS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLPVKWTAPE
Binding pocket
QTIGKGEFGDVMLVAVKCIAFLAEASVMTQLRSNLVQLLGVYIVTEYMAKGSLVDYLRSYLEGNNFVHRDLAARNVLVVSDFGLT
Ligand info
Orthosteric ligand
None
Allosteric ligand
None
Ligand typeNo_ligand
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3D7U, Chain A