3D7T Chain A
Tyrosine-protein kinase CSK (CSK)
Inactive — 0.0%DFG-inαC-inType1 · STU
Resolution
2.9 Å
R-value
0.239
Predicted activity confidence0.0%
Structure info
Alternate conformation—
Missing atoms0
Missing residues2
Salt bridge (KinCore)Saltbr-in
Sequence info
PDB sequence
WALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGPVKWTAPEALREAAFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
UniProt reference sequence
LKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH
Aligned reference sequence
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--NDAT------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEEK--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFGLTKEASSTQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTGKLPVKWTAPEALRE--------------------------------KKFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
LKLL----------------QTIGKGE----------------FGDVMLGDY----------------------------------------RGNKVAVKCIK--NDAT------------------------------AQAFLAEASVMTQL--------------------------RHSNLVQLLGVIVEEK--G-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLYIVTEYMAK--------------GSLVDYLRS--RGRS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLGGDCLLKFSLDVCEAMEYLEGN---------------------------------------------NFVHRDL-----AARNVLVSE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DNVAKVSDFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWTAPEALRE--------------------------------AAFS-TKSDVWSFGILLWEIYSF--G--------------RVPYPR--------------------------------------------------IPLKDVVPRVEKG--YKMDAPDGCP-----------------------------------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS--------------FLQLREQLEH
Activation segment
DFG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVKWTAPE
Binding pocket
QTIGKGEFGDVMLVAVKCIAFLAEASVMTQLRSNLVQLLGVYIVTEYMAKGSLVDYLRSYLEGNNFVHRDLAARNVLVVSDFG__
Ligand info
Orthosteric ligand
STU
Allosteric ligand
None
Ligand typeType1
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityinactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3D7T, Chain A