3D14 Chain A
Aurora kinase A (AURKA)
Active — 61.4%DFG-inαC-inType1.5_Front · AK1
Resolution
1.9 Å
R-value
0.213
Predicted activity confidence61.4%
Structure info
Alternate conformationA
Missing atoms11
Missing residues0
Salt bridge (KinCore)Saltbr-out
Sequence info
PDB sequence
GPLGSRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSS
UniProt reference sequence
FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI
Aligned reference sequence
FEIG----------------RPLGKGK----------------FGNVYLARE--KQ------------------------------------SKFILALKVLF--KAQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGELKIADFGWSVHAPSSRR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLCGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------KPPFEA--------------------------------------------------NTYQETYKRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM--------------LREVLEHPWI
Shaded segments mark residues present in the UniProt reference but not resolved in this structure.
Projected alignment
FDIG----------------RPLGKGK----------------FGNVYLARE--RQ------------------------------------SKFILALKVLF--KTQLEKAGV-------------------------EHQLRREVEIQSHL--------------------------RHPNILRLYGYFHDAT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RVYLILEYAPL--------------GTVYRELQK--LS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RFDEQRTATYITELANALSYCHSK---------------------------------------------RVIHRDI-----KPENLLLGS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NGELKIADFGWSVHAPS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTLDYLPPEMIEG--------------------------------RMHD-EKVDLWSLGVLCYEFLVG-----------------MPPFEA--------------------------------------------------HTYQETYRRISRV--EFTFPDFVT------------------------------------------------------------------------------------------------------EGARDLISRLLKHNASQRLT--------------LAEVLEHPWI
Activation segment
DFGWSVHAPS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------CGTLDYLPPE
Binding pocket
RPLGKGKFGNVYLLALKVLQLRREVEIQSHLRPNILRLYGYYLILEYAPLGTVYRELQKYCHSKRVIHRDIKPENLLLIADFGWS
Ligand info
Orthosteric ligand
AK1
Allosteric ligand
None
Ligand typeType1.5_Front
Consensus conformation
DFG conformationin
αC-helix conformationin
Predicted activityactive
KinaDB — structure detail · data from Browse_each_pdb_structure.csv · PDB 3D14, Chain A